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Article

The 15-Amino Acid Repeat Region of Adenomatous Polyposis Coli Is Intrinsically Disordered and Retains Conformational Flexibility upon Binding β-Catenin.

Biochemistry - 20 Oct 2020

Rudeen Aaron J, Douglas Justin T, Xing Minli, McDonald W Hayes, Lamb Audrey L, Neufeld Kristi L

Abstract excerpt

The tumor suppressor Adenomatous polyposis coli (APC) is a large, multidomain protein with many identified cellular functions. The best characterized role of APC is to scaffold a protein complex that negatively regulates Wnt signaling via β-catenin destruction. This destruction is mediated by β-catenin binding to centrally located 15- and 20-amino acid repeat regions of APC. More than 80% of cancers of the colon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32941008
DOI: 10.1021/acs.biochem.0c00479
PMCID: PMC8771494

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