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Article

Structuring of the 3' splice site by U2AF65.

The Journal of biological chemistry - 12 Dec 2003

Kent Oliver A, Reayi Ayube, Foong Louise, Chilibeck Kaari A, MacMillan Andrew M

Abstract excerpt

Recognition of the 3' splice site in mammalian introns is accomplished by association of the splicing factor U2AF with the precursor mRNA (pre-mRNA) in a multiprotein splicing commitment complex. It is well established that this interaction involves binding of the large U2AF65 subunit to sequences upstream of the 3' splice site, but the orientation of the four domains of this protein with respect to the RNA and...

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Identifiers

PMID: 14506271
DOI: 10.1074/jbc.M307976200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Structuring of the 3' splice site by U2AF65.PMID 14506271Read ↗

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.Semantic proximity Read ↗

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Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.Semantic proximity Read ↗

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.Semantic proximity Read ↗

Structural studies of spliceosome assembly and catalysisSemantic proximity Read ↗

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site SignalSemantic proximity Read ↗

Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Semantic proximity Read ↗

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated MutationSemantic proximity Read ↗

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Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interactionSemantic proximity Read ↗

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