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Article

Structuring of the 3' splice site by U2AF65.

The Journal of biological chemistry - 12 Dec 2003

Kent Oliver A, Reayi Ayube, Foong Louise, Chilibeck Kaari A, MacMillan Andrew M

Abstract excerpt

Recognition of the 3' splice site in mammalian introns is accomplished by association of the splicing factor U2AF with the precursor mRNA (pre-mRNA) in a multiprotein splicing commitment complex. It is well established that this interaction involves binding of the large U2AF65 subunit to sequence...

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Identifiers

PMID: 14506271
DOI: 10.1074/jbc.M307976200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14506271-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structuring of the 3' splice site by U2AF65.PMID 14506271Read ↗

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.Semantic proximity Read ↗

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Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.Semantic proximity Read ↗

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.Semantic proximity Read ↗

Structural studies of spliceosome assembly and catalysisSemantic proximity Read ↗

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site SignalSemantic proximity Read ↗

Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Semantic proximity Read ↗

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated MutationSemantic proximity Read ↗

Structural insights into how Prp5 proofreads the pre-mRNA branch site.Semantic proximity Read ↗

Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interactionSemantic proximity Read ↗

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