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The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

29 Mar 2021

Abstract excerpt

Metabolic enzymes and metabolites display non-metabolic functions in immune cell signalling that modulate immune attack ability. However, whether and how a tumour's metabolic remodelling contributes to its immune resistance remain to be clarified. Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate...

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PMID: 33782411
DOI: 10.1038/s41467-021-22173-5

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