Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated<i>Plasmodium falciparum</i>sporozoite vaccine

Abstract excerpt

Annually, malaria causes >300 million clinical cases and 1 million deaths, is responsible for the loss of >1% of gross domestic product (GDP) in Africa and is a serious concern for travelers. An effective vaccine could have a dramatic impact on the disease. For 20 years, scientists have tried to develop modern, recombinant 'subunit' malaria vaccines. This has been difficult. In fact, there is only one recombinant...

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