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Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8 <sup>+</sup> T Cell Immunity

9 Sept 2011

Abstract excerpt

Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in ≥80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are the only immunogens shown to induce such protection in humans. Such protection is thought to be mediated by CD8(+) T cells in the liver that secrete interferon-γ (IFN-γ). We report that purified irradiated PfSPZ administered to 80 volunteers...

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PMID: 21903775
DOI: 10.1126/science.1211548

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