Article
Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice.
Neurobiology of disease - 1 Dec 2001
Kulnane L S, Lamb B T
Abstract excerpt
Mutations in the amyloid precursor protein (APP) gene result in elevated production and deposition of the 42 amino acid beta-amyloid (Abeta1-42) peptide and early-onset Alzheimer's disease (AD). To accurately examine the effect of the APP FAD mutations in vivo, we introduced yeast artificial chromosomes (YACs) containing the entire genomic copy of human APP harboring FAD mutations into transgenic mice. Our...
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