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Article

Characterization of the 5’flanking Region of the Human chk1 Gene: Identification of E2F1 Functional Sites

28 Nov 2003

Abstract excerpt

Chk1 kinase is a key signal transducer in the checkpoint pathways responding to DNA damage. Chk1 has been shown to be transcriptionally down-regulated in response to cis-dichloro-diamino platinum treatment in a p53-dependent manner. Now we isolated and characterised the 5' flanking region of the Chk1 gene. We demonstrated that the isolated region has promoter activity when cloned upstream to a reporter luciferase...

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Identifiers

PMID: 14504477
DOI: 10.4161/cc.2.6.503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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