Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells

30 May 2003

Abstract excerpt

Ionizing radiation damages chromosomal DNA and activates p53-dependent transcription in mammalian cells. The Chk2 protein kinase has been hypothesized to be the primary mediator of this response. We have rigorously tested this hypothesis in human cells by disrupting the CHK2 gene through homologous recombination. We found that the p53 response was unexpectedly robust in such cells. Phosphorylation of p53 at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12654917
DOI: 10.1074/jbc.m213159200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer CellsPMID 12654917Read ↗

Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.Semantic proximity Read ↗

Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage ResponseSemantic proximity Read ↗

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.Semantic proximity Read ↗

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.Semantic proximity Read ↗

The Chk2 protein kinase.Semantic proximity Read ↗

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.Semantic proximity Read ↗

p53-Independent Regulation of p21Waf1/Cip1 Expression and Senescence by Chk2Semantic proximity Read ↗

CHK2 kinase--a busy messenger.Semantic proximity Read ↗

Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrestSemantic proximity Read ↗

Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agentsSemantic proximity Read ↗

Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.Semantic proximity Read ↗

Characterization of tumor-associated Chk2 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.