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Article

Chk2 activates E2F-1 in response to DNA damage.

Nature cell biology - 1 May 2003

Stevens Craig, Smith Linda, La Thangue Nicholas B

Abstract excerpt

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 consensus phosphorylation site in E2F-1 is phosp...

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Identifiers

PMID: 12717439
DOI: 10.1038/ncb974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12717439-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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