Article
Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations.
Blood - 15 Jan 2004
Damle Rajendra N, Batliwalla Franak M, Ghiotto Fabio, Valetto Angelo, Albesiano Emilia, Sison Cristina, Allen Steven L, Kolitz Jonathan, Vinciguerra Vincent P, Kudalkar Prasad, Wasil Tarun, Rai Kanti R, Ferrarini Manlio, Gregersen Peter K, Chiorazzi Nicholas
Abstract excerpt
Patients with B-cell chronic lymphocytic leukemia (B-CLL) segregate into subgroups with very different survival times. Because clinical observations suggest that leukemic cells accumulate at different rates, we measured telomere length and telomerase activity in B-CLL cells to distinguish differences in cellular replication. Our data indicate that the telomeres of B-CLL cells are shorter than telomeres of B cells...
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