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Article

Association between telomere length and V(H) gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications.

British journal of cancer - 24 Feb 2003

Hultdin M, Rosenquist R, Thunberg U, Tobin G, Norrback K-F, Johnson A, Sundström C, Roos G

Abstract excerpt

The immunoglobulin V(H) gene mutation status can divide B-cell chronic lymphocytic leukaemia (CLL) into two entities with a different clinical course. Cases with unmutated V(H) genes, considered to evolve from pregerminal centre (GC) cells, have a worse outcome compared to cases showing mutated V(H) genes, that is, post-GC derived. Also, telomere length has been reported to be of prognostic significance in CLL....

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Share to Telomere
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Immunoglobulin

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 12592375
DOI: 10.1038/sj.bjc.6600763
PMCID: PMC2377180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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