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Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1 May 1994

Abstract excerpt

We have measured telomere length and telomerase activity throughout the life span of clones of human B lymphocytes transformed by Epstein-Barr virus. Shortening of telomeres occurred at similar rates in all populations and persisted until chromosomes had little telomeric DNA remaining. At this stage, some of the clones entered a proliferative crisis and died. Only clones in which telomeres were stabilized,...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 8151802
DOI: 10.1128/jvi.68.5.3410-3414.1994

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