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Article

Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes.

BMC cancer - 3 Feb 2022

Olbertova Helena, Plevova Karla, Pavlova Sarka, Malcikova Jitka, Kotaskova Jana, Stranska Kamila, Spunarova Michaela, Trbusek Martin, Navrkalova Veronika, Dvorackova Barbara, Tom Nikola, Pal Karol, Jarosova Marie, Brychtova Yvona, Panovska Anna, Doubek Michael, Pospisilova Sarka

Abstract excerpt

BACKGROUND: Telomeres are protective structures at chromosome ends which shorten gradually with increasing age. In chronic lymphocytic leukemia (CLL), short telomeres have been associated with unfavorable disease outcome, but the link between clonal evolution and telomere shortening remains unresolved. METHODS: We investigated relative telomere length (RTL) in a well-characterized cohort of 198 CLL patients by...

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Share to Clonal Evolution
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Signal Transduction

Share to Telomerase

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 35114947
DOI: 10.1186/s12885-022-09221-z
PMCID: PMC8812042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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