Article
Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status.
Blood - 15 Jun 2005
Grabowski Pawel, Hultdin Magnus, Karlsson Karin, Tobin Gerard, Aleskog Anna, Thunberg Ulf, Laurell Anna, Sundström Christer, Rosenquist Richard, Roos Göran
Abstract excerpt
B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the prognostic value of telomere length has not been fully established in CLL. We analyzed telomere...
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