Article
S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.
Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2011
Qu Jing, Nakamura Tomohiro, Cao Gang, Holland Emily A, McKercher Scott R, Lipton Stuart A
Abstract excerpt
The activity of Cdk5 and its regulatory subunit p35 is thought to be important in both normal brain function and neurodegenerative disease pathogenesis. Increased Cdk5 activity, via proteolytic cleavage of p35 to a p25 fragment by the calcium-activated protease calpain or by phosphorylation at Cdk5(Tyr15), can contribute to neurotoxicity. Nonetheless, our knowledge of regulation of Cdk5 activity in disease states...
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