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Article

Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action.

Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2005

Araki Osamu, Ying Hao, Furuya Fumihiko, Zhu Xuguang, Cheng Sheue-Yann

Abstract excerpt

Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone receptors (TR) and peroxisome proliferator-activated receptors (PPAR). We recently found that a dominantly negative TRbeta mutant (PV) that causes a genetic disease, resistance to thyroid hormone, acts to repress the...

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Identifiers

PMID: 16260719
DOI: 10.1073/pnas.0508556102
PMCID: PMC1283481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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