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Article

Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo.

Breast cancer research : BCR - 1 Jan 2005

Wang Yi-hua, Liu Shuang, Zhang Guo, Zhou Cui-qi, Zhu Hong-xia, Zhou Xiao-bo, Quan Lan-ping, Bai Jin-feng, Xu Ning-zhi

Abstract excerpt

INTRODUCTION: Breast cancer is the leading cause of cancer death in women worldwide. Elevated expression of c-Myc is a frequent genetic abnormality seen in this malignancy. For a better understanding of its role in maintaining the malignant phenotype, we used RNA interference (RNAi) directed against c-Myc in our study. RNAi provides a new, reliable method to investigate gene function and has the potential for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15743499
DOI: 10.1186/bcr975
PMCID: PMC1064129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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