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Article

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.

The Journal of clinical investigation - 1 Feb 2018

Lin Wen, Li Deqiang, Cheng Lan, Li Li, Liu Feiyan, Hand Nicholas J, Epstein Jonathan A, Rader Daniel J

Abstract excerpt

Isolated left ventricular noncompaction (LVNC) results from excessive trabeculation and impaired myocardial compaction during heart development. The extracellular matrix (ECM) that separates endocardium from myocardium plays a critical but poorly understood role in ventricular trabeculation and compaction. In an attempt to characterize solute carrier family 39 member 8-null (Slc39a8-null) mice, we discovered that...

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Share to Cation Transport Proteins
Share to Endocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Heart Ventricles

Share to Human Umbilical Vein Endothelial Cells

Share to Ventricular Dysfunction, Left

Source

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Identifiers

PMID: 29337306
DOI: 10.1172/JCI96993
PMCID: PMC5785267

Genes

ADAMTS1

Provenance

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