Article
Assessment of genotoxic effects by lindane.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Apr 1993
Pool-Zobel B L, Guigas C, Klein R, Neudecker C, Renner H W, Schmezer P
Abstract excerpt
The well known and previously widespread insecticide lindane has been re-assessed for DNA-damaging activity. A first group of investigations using standard in vitro and in vivo mutagenicity assays did not indicate any genotoxic effects of lindane at all. The assay systems used were for the induction of HPRT mutations and sister chromatid exchanges in CHO cells cultured in vitro, and for micronuclei induction in...
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