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Article

Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions.

Clinical pharmacology and therapeutics - 1 Jul 2018

Storelli Flavia, Matthey Alain, Lenglet Sébastien, Thomas Aurélien, Desmeules Jules, Daali Youssef

Abstract excerpt

We investigated whether CYP2D6 extensive metabolizers carrying a nonfunctional allele are at higher risk of phenoconversion to poor metabolizers in the presence of CYP2D6 inhibitors. Seventeen homozygous carriers of two fully-functional alleles and 17 heterozygous carriers of one fully-functional and one nonfunctional allele participated in this trial. Dextromethorphan 5 mg and tramadol 10 mg were given at each...

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Identifiers

PMID: 28940476
DOI: 10.1002/cpt.889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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