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Article

Rescue of ligand binding of a mutant IGF-I receptor by complementation.

Biochemical and biophysical research communications - 27 May 2005

Chakravarty Anders, Hinrichsen Jane, Whittaker Linda, Whittaker Jonathan

Abstract excerpt

The IGF-I receptor binds IGF-I with complex kinetics characterized by a curvilinear Scatchard plot, suggesting receptor heterogeneity and apparent negative cooperativity. To explore the molecular mechanisms underlying these properties, we have characterized the binding of a hybrid receptor formed from a wild-type receptor monomer and a mutant receptor monomer devoid of binding activity. Receptor hybrids were...

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PMID: 15845360
DOI: 10.1016/j.bbrc.2005.03.122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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