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Article

Growth on type I collagen promotes expression of the osteoblastic phenotype in human osteosarcoma MG-63 cells.

Journal of cellular physiology - 1 Nov 1992

Andrianarivo A G, Robinson J A, Mann K G, Tracy R P

Abstract excerpt

Using MG-63 cells as a model system capable of partial osteoblastic differentiation, we have examined the effect of growth on extracellular matrix. MG-63 cell matrix and purified type I collagen induced a morphological change characterized by long cytoplasmic processes reminiscent of those seen in osteocytes. Concurrent biochemical changes involving bone marker proteins included increased specific activity of...

Topics

Alkaline Phosphatase
Animals
Bone and Bones
Calcitriol
Cell Division
Collagen
Humans
Osteoblasts
Osteonectin
Osteosarcoma
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Species Specificity

Substrate Specificity

Time Factors

Transforming Growth Factor beta

Tumor Cells, Cultured

Source

Identifiers

PMID: 1429847
DOI: 10.1002/jcp.1041530205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1429847-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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