Article
Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 1991
Hiraki Y, Inoue H, Shigeno C, Sanma Y, Bentz H, Rosen D M, Asada A, Suzuki F
Abstract excerpt
We studied the effects of highly purified bone morphogenetic protein 2 and 3 (BMP-2 and -3) on growth plate chondrocytes and osteoblastic cells in vitro and compared to TGF-beta. A mixture of BMP-2 and 3 (BMPs) strongly stimulated DNA synthesis of chondrocytes in the presence of fibroblast growth...
Topics
- Alkaline Phosphatase
- Animals
- Bone Morphogenetic Protein 3
- Bone Morphogenetic Proteins
- Cartilage
- Cell Differentiation
- Cell Division
- Cell Line
- Cellular Senescence
- Growth Substances
- Osteoblasts
- Parathyroid Hormone
- Phenotype