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Article

Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation.

Molecular medicine (Cambridge, Mass.) - 1 Jul 2002

Bodo Maria, Lilli Cinzia, Bellucci Catia, Carinci Paolo, Calvitti Mario, Pezzetti Furio, Stabellini Giordano, Bellocchio Silvia, Balducci Chiara, Carinci Francesco, Baroni Tiziano

Abstract excerpt

BACKGROUND: We focused on the phenotype of non-mineralizing MG 63 and mineralizing TE 85 human osteosarcoma cells and investigated the role of bFGF in modulating their differentiative responses. Basic FGF expression and bFGF effects on osteocalcin, runt-related transcription factor-2 (RUNX2), matrix molecular production and bFGF receptors, were evaluated. MATERIALS AND METHODS: Osteocalcin and RUNX2 gene...

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Identifiers

PMID: 12393937
PMCID: PMC2040003

Genes

RUNX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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