Article
Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repression.
The Journal of biological chemistry - 15 Nov 1992
Dueland S, Trawick J D, Nenseter M S, MacPhee A A, Davis R A
Abstract excerpt
The goal of this study was to understand why the expression of low density lipoprotein (LDL) receptors by the liver is poorly down-regulated by cholesterol. We examined the hypothesis that 7 alpha-hydroxylase may indirectly induce the expression of the LDL receptor by metabolizing, i.e. inactivat...
Topics
- Actins
- Animals
- Aryl Hydrocarbon Hydroxylases
- CHO Cells
- Cholesterol
- Cholesterol Esters
- Cricetinae
- Cytochrome P-450 Enzyme System
- Drug Resistance
- Hydroxycholesterols
- Liver
- Phenotype
- RNA, Messenger
- Rats
- Receptors, LDL
- Steroid Hydroxylases
- Transfection