Article
Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repression.
The Journal of biological chemistry - 15 Nov 1992
Dueland S, Trawick J D, Nenseter M S, MacPhee A A, Davis R A
Abstract excerpt
The goal of this study was to understand why the expression of low density lipoprotein (LDL) receptors by the liver is poorly down-regulated by cholesterol. We examined the hypothesis that 7 alpha-hydroxylase may indirectly induce the expression of the LDL receptor by metabolizing, i.e. inactivating oxysterol repressors. Non-hepatic Chinese hamster ovary cells, transfected with a plasmid encoding 7...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.