Article
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration.
Atherosclerosis - 1 Sept 2005
Abrahamsson Anna, Krapivner Sergey, Gustafsson Ulf, Muhrbeck Olle, Eggertsen Gösta, Johansson Inger, Persson Irene, Angelin Bo, Ingelman-Sundberg Magnus, Björkhem Ingemar, Einarsson Curt, van't Hooft Ferdinand M
Abstract excerpt
Transcriptional regulation of the cholesterol 7alpha-hydroxylase (CYP7AI) gene is of critical importance for bile acid and cholesterol metabolism. We evaluated the physiological significance of two common polymorphisms (-203C/A and -469T/C) in the promoter region of the CYP7AI gene. No evidence was found for physiological differences between either the -203C and -203A alleles or the -469T and -469C alleles in...
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