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Article

Relative contribution of HLA-DQA and -DQB alleles to predisposition to insulin-dependent diabetes mellitus.

Human immunology - 1 Jun 1992

Giphart M J, Roep B O, Drabbels J, D'Amaro J, Bruining G J, Abdulkadir J, Verduyn W

Abstract excerpt

The presence of DQA and DQB alleles conferring protection or susceptibility was assessed in a panel of 39 insulin-dependent diabetes mellitus patients and 39 healthy control subjects from the central highland of Ethiopia. The results were grouped into three entities: a combination of alleles conferring susceptibility, a group conferring protection, and a group without any apparent HLA-DQ or -DR predisposition to...

Topics

Alleles
Autoimmune Diseases
Black People
Diabetes Mellitus, Type 1
Disease Susceptibility
Ethiopia
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ beta-Chains

Humans

Polymerase Chain Reaction

Predictive Value of Tests

Risk

Source

Identifiers

PMID: 1429035
DOI: 10.1016/0198-8859(92)90040-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1429035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Relative contribution of HLA-DQA and -DQB alleles to predisposition to insulin-dependent diabetes mellitus.PMID 1429035Read ↗

Susceptibility alleles at HLA-DRB1, -DQA1, and -DQB1 loci in Ethiopian childhood insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Semantic proximity Read ↗

Combinations of HLA DR and DQ molecules determine the susceptibility to insulin-dependent diabetes mellitus in Koreans.Semantic proximity Read ↗

Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

Insulin dependent diabetes mellitus susceptibility or protection may be determined by certain HLA-DQ molecules.Semantic proximity Read ↗

Increased and decreased relative risk for non-insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles.Semantic proximity Read ↗

Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

Contribution of DRB1*04 variants to predisposition to or protection from insulin dependent diabetes mellitus is independent of dq.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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