Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two-locus models of disease.

Genetic epidemiology - 1 Jan 1992

Neuman R J, Rice J P

Abstract excerpt

Most complex diseases have not been amenable to genetic analysis under the assumption of single locus or multifactorial models. Consequently, interest has turned to the consideration of the properties of oligogenic models. i.e., genetic models involving a small number of genes. Nine two-locus models of disease, representing both epistatic and heterogeneous genetic models, are investigated: three models of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Genetic Diseases, Inborn
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mathematics

Share to Models, Genetic

Share to Prevalence

Share to Risk Factors

Share to Schizophrenia

Source

Identifiers

PMID: 1427023
DOI: 10.1002/gepi.1370090506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two-locus models of disease.PMID 1427023Read ↗

Restrictions on components of variance for epistatic models.Semantic proximity Read ↗

Exchangeable models of complex inherited diseases.Semantic proximity Read ↗

A complete enumeration and classification of two-locus disease models.Semantic proximity Read ↗

A perspective on epistasis: limits of models displaying no main effect.Semantic proximity Read ↗

Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.Semantic proximity Read ↗

General epistatic models of the risk of complex diseases.Semantic proximity Read ↗

Evidence and implications for multiplicative interactions among loci predisposing to human common disease.Semantic proximity Read ↗

The mathematical limits of genetic prediction for complex chronic disease.Semantic proximity Read ↗

Philipp Jolly and his 1913 "the heredity of psychosis": Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic-depressive illness and dementia praecox.Semantic proximity Read ↗

A complete classification of epistatic two-locus models.Semantic proximity Read ↗

Phenocopies versus genetic heterogeneity: can we use phenocopy frequencies in linkage analysis to compensate for heterogeneity?Semantic proximity Read ↗

Estimation of disease risk under bivariate models of multifactorial inheritance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.