Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.

American journal of human genetics - 1 Sept 1995

Craddock N, Khodel V, Van Eerdewegh P, Reich T

Abstract excerpt

We describe a simple, graphical method for determining plausible modes of inheritance for complex traits and apply this to bipolar disorder. The constraints that allele frequencies and penetrances lie in the interval 0-1 impose limits on recurrence risks, KR, in relatives of an affected proband for a given population prevalence, KP. We have investigated these limits for KR in three classes of relatives (MZ...

Topics

Alleles
Bipolar Disorder
Genetic Heterogeneity
Genetics, Population
Humans
Models, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7668299
PMCID: PMC1801283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7668299-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.PMID 7668299Read ↗

Exchangeable models of complex inherited diseases.Semantic proximity Read ↗

Two-locus models of disease.Semantic proximity Read ↗

General epistatic models of the risk of complex diseases.Semantic proximity Read ↗

Family, twin, and adoption studies of bipolar disorder.Semantic proximity Read ↗

Restrictions on components of variance for epistatic models.Semantic proximity Read ↗

The effect of co-morbidity and penetrance estimation on the outcome of linkage analysis in a bipolar family.Semantic proximity Read ↗

The relationship between the sibling recurrence-risk ratio and genotype relative risk.Semantic proximity Read ↗

Multiplex relative risk and estimation of the number of loci underlying an inherited disease.Semantic proximity Read ↗

Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation.Semantic proximity Read ↗

Patterns of parental transmission and familial aggregation models in bipolar affective disorder.Semantic proximity Read ↗

Estimating multilocus linkage disequilibria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.