Article
Differential regulation of vitamin D receptor expression in distinct leukemic cell lines upon phorbol ester-induced growth arrest.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 May 2000
Folgueira M A, Federico M H, Roela R A, Maistro S, Katayama M L, Brentani M M
Abstract excerpt
A close correlation between vitamin D receptor (VDR) abundance and cell proliferation rate has been shown in NIH-3T3 fibroblasts, MCF-7 breast cancer and in HL-60 myeloblastic cells. We have now determined if this association occurs in other leukemic cell lines, U937 and K562, and if VDR content is related to c-myc expression, which is also linked to cell growth state. Upon phorbol myristate acetate (PMA)...
Topics
- Antibodies, Monoclonal
- Carcinogens
- Cell Differentiation
- Down-Regulation
- Fluorescent Antibody Technique
- Gene Expression Regulation, Neoplastic
- Growth Inhibitors
- HL-60 Cells
- Humans
- K562 Cells
- Leukemia
- Phenotype
- RNA