Article
Novel vitamin D3 derivatives, 26-homo-delta 22-dehydro-1 alpha,25(S)-dihydroxyvitamin D3 and 26-homo-delta 22-dehydro-1 alpha,25(R)-dihydroxyvitamin D3: preferential activity in c-myc mRNA production and in induction of phenotypic differentiation of HL-60 cells.
Archives of biochemistry and biophysics - 1 Feb 1990
Koizumi T, Nakao Y, Ishizuka S, Oshida J, Hara N, Ikekawa N, Fijita T
Abstract excerpt
Novel vitamin D3 derivatives, 26-homo-delta 22-1 alpha,25(S)-dihydroxyvitamin D3 and 26-homo-delta 22-1 alpha,25(R)-dihydroxyvitamin D3 were compared with the native hormone, 1,25-dihydroxyvitamin D3, and with other vitamin D3 derivatives, in inhibition of cell growth, induction of phenotypic differentiation, and c-myc mRNA reduction of HL-60 cells. The degree of inhibition in cell growth caused by 26-homo-delta...
Topics
- Calcitriol
- Cell Differentiation
- Cell Division
- Cell Line
- Humans
- Kinetics
- Leukemia, Promyelocytic, Acute
- Nucleic Acid Hybridization
- Phenotype
- Protein-Tyrosine Kinases