Mutation in the ligand-binding domain of the retinoic acid receptor alpha in HL-60 leukemic cells resistant to retinoic acid and with increased sensitivity to vitamin D3 analogs.

doi:10.1016/0145-2126(96)00043-4

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Article

Mutation in the ligand-binding domain of the retinoic acid receptor alpha in HL-60 leukemic cells resistant to retinoic acid and with increased sensitivity to vitamin D3 analogs.

Leukemia research - 1 Sept 1996

Doré B T, Momparler R L

Abstract excerpt

Even though retinoic acid can induce complete remissions in patients with acute promyelocytic leukemia, the duration of response is short and further therapy with this agent is less effective, suggesting the development of drug resistance. One possible way to overcome this problem is to use retin...

Topics

Antineoplastic Agents
Calcitriol
Cell Differentiation
Cell Division
Drug Resistance, Neoplasm
Drug Synergism
HL-60 Cells
Humans
Leukemia, Promyelocytic, Acute
Mutation
Receptors, Retinoic Acid
Retinoic Acid Receptor alpha
Tretinoin

Source

Open in PubMed

Identifiers

PMID: 8947586
DOI: 10.1016/0145-2126(96)00043-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8947586-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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