Article
A retinoic acid resistant HL-60 cell clone sensitive to N-(4-hydroxyphenyl) retinamide-mediated clonal growth inhibition.
Leukemia & lymphoma - 1 Mar 1995
Brigati C, Ferrari N, Megna M, Roncella S, Cutrona G, Tosetti F, Vidali G
Abstract excerpt
Among the Retinoic Acid (RA) derivatives, retinamides, and in particular N-(4-hydroxyphenyl) retinamide (4-HPR), are currently being investigated in selected cases of cancer chemoprevention. The cellular target range, however, seems to be limited, as cells of hemopoietic origin are virtually inca...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Clone Cells
- Dimethyl Sulfoxide
- Drug Resistance
- Drug Screening Assays, Antitumor
- Fenretinide
- Flow Cytometry
- Leukemia, Myeloid
- Mice
- Phenotype
- Tretinoin
- Tumor Cells, Cultured