Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone.

doi:10.1210/endo.131.5.1425421

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Article

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone.

Endocrinology - 1 Nov 1992

Ohsaki Y, Takahashi S, Scarcez T, Demulder A, Nishihara T, Williams R, Roodman G D

Abstract excerpt

Interleukin-6 (IL-6) is a multifunctional cytokine whose role in osteoclastic bone resorption has not been clearly defined. Therefore, we have used giant cells, which express many features of osteoclasts, from giant cell tumors of bone as a model to examine the role that IL-6 may play in human os...

Topics

Base Sequence
Bone Neoplasms
Bone Resorption
Culture Media, Conditioned
DNA, Neoplasm
Dose-Response Relationship, Drug
Gene Expression Regulation, Neoplastic
Giant Cell Tumors
Humans
Immunohistochemistry
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-6

Molecular Sequence Data

Phenotype

Polymerase Chain Reaction

RNA, Messenger

Receptors, Immunologic

Receptors, Interleukin-6

Source

Open in PubMed

Identifiers

PMID: 1425421
DOI: 10.1210/endo.131.5.1425421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1425421-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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