Article
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 1996
Kotake S, Sato K, Kim K J, Takahashi N, Udagawa N, Nakamura I, Yamaguchi A, Kishimoto T, Suda T, Kashiwazaki S
Abstract excerpt
Chronic immune responses and inflammatory reactions in rheumatoid arthritis (RA) often cause severe destruction of cartilage and bone, but its mechanism is still a matter of controversy. We reported that interleukin-6 (IL-6) alone does not induce osteoclast formation, but soluble interleukin-6 re...
Topics
- Acid Phosphatase
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antigens, CD
- Arthritis, Rheumatoid
- Cells, Cultured
- Female
- Humans
- Interleukin-6
- Male
- Mice
- Middle Aged