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Article

Expression of Osteoclast Differentiation Signals by Stromal Elements of Giant Cell Tumors

1 Apr 2000

Abstract excerpt

The mechanisms by which primary tumors of the bone cause bone destruction have not been elucidated. Unlike most other lytic bone tumors, osteoclastomas, otherwise known as giant cell tumors (GCT), contain osteoclast-like cells within the tumor stroma. A new member of the TNF-ligand superfamily member, osteoclast differentiation factor (ODF/OPGL/RANKL/TRANCE), was recently identified. ODF was shown to directly...

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PMID: 10780856
DOI: 10.1359/jbmr.2000.15.4.640

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