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Article

Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab.

PloS one - 1 Jan 2016

Mukaihara Kenta, Suehara Yoshiyuki, Kohsaka Shinji, Akaike Keisuke, Tanabe Yu, Kubota Daisuke, Ishii Midori, Fujimura Tsutomu, Kazuno Saiko, Okubo Taketo, Takagi Tatsuya, Yao Takashi, Kaneko Kazuo, Saito Tsuyoshi

Abstract excerpt

Giant cell tumors of bone (GCTB) are locally aggressive osteolytic bone tumors. Recently, some clinical trials have shown that denosumab is a novel and effective therapeutic option for aggressive and recurrent GCTB. This study was performed to investigate the molecular mechanism underlying the therapeutic effect of denosumab. Comparative proteomic analyses were performed using GCTB samples which were taken before...

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Identifiers

PMID: 26863138
DOI: 10.1371/journal.pone.0148401
PMCID: PMC4749282

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