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Article

Spindle-shaped cells derived from giant-cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 2000

Miyamoto N, Higuchi Y, Tajima M, Ito M, Tsurudome M, Nishio M, Kawano M, Sudo A, Uchida A, Ito Y

Abstract excerpt

Spindle-shaped cells were established from four giant-cell tumors of bone. When human blood monocytes were co-cultured with these cells, multinucleated giant-cell formation of monocytes was induced. Intriguingly, even when a filter (pore size: 0.45 microm) was interposed between monocytes and the spindle-shaped cells, polykaryocytes also appeared. These multinucleated giant cells were positive for...

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PMID: 11052502
DOI: 10.1002/jor.1100180418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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