Article
Cellular mechanisms of osteoclast formation and lacunar resorption in giant cell granuloma of the jaw.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Apr 2003
Itonaga I, Hussein I, Kudo O, Sabokbar A, Watt-Smith S, Ferguson D, Athanasou N A
Abstract excerpt
BACKGROUND: Giant cell granuloma (GCG) is an osteolytic tumour of the jaw which is characterised by the presence of both mononuclear and multinucleated (osteoclast-like) giant cell components. The nature of these component cells and the pathogenesis of the extensive osteolysis associated with this lesion is uncertain. METHODS: Using cell culture techniques and immunohistochemistry, we defined the phenotypic...
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