Article
Generation of cytotoxicity with various MHC class I restrictions against autologous LCL by stimulating the lymphocytes with autologous and/or allogeneic LCLs sharing HLA alleles with the responder.
Cellular immunology - 1 Nov 1992
Stuber G, Avila-Cariño J, Klein E
Abstract excerpt
We exposed human blood lymphocytes to autologous and to allogeneic lymphoblastoid lines (LCLs), each alone or in combination, and analyzed the MHC Class I restriction pattern of the generated auto-LCL reactive cytotoxicity. In the cultures of two EBV-seropositive, HLA A11-positive individuals the majority of cytotoxic lymphocytes generated after repeated stimulation with autologous LCL were restricted by this...
Topics
- Alleles
- Cell Line
- Cytotoxicity, Immunologic
- HLA Antigens
- Histocompatibility Antigens Class I
- Humans
- Infant, Newborn
- Lymphocyte Activation
- T-Lymphocytes, Cytotoxic