Article
Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002
Romagnani Chiara, Pietra Gabriella, Falco Michela, Millo Enrico, Mazzarino Paola, Biassoni Roberto, Moretta Alessandro, Moretta Lorenzo, Mingari Maria Cristina
Abstract excerpt
Previous studies showed that a subset of CD8(+) cytolytic T lymphocytes expressing HLA class I-specific natural killer inhibitory receptors (iNKR) is characterized by the ability to recognize HLA-E and to mediate T cell receptor-dependent killing of different NK cell-susceptible tumor target cells. In this study, we show that this CD8(+) T cell subset can also undergo extensive proliferation in mixed lymphocyte...
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