Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implications of epidermal growth factor (EGF) induced egf receptor aggregation.

Biophysical journal - 1 Jul 1992

Wofsy C, Goldstein B, Lund K, Wiley H S

Abstract excerpt

To investigate the role of receptor aggregation in EGF binding, we construct a mathematical model describing receptor dimerization (and higher levels of aggregation) that permits an analysis of the influence of receptor aggregation on ligand binding. We answer two questions: (a) Can Scatchard plots of EGF binding data be analyzed productively in terms of two noninteracting receptor populations with different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to ErbB Receptors
Share to EGF gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetics

Share to Models, Biological

Share to Mutation

Share to Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 1420877
DOI: 10.1016/S0006-3495(92)81572-2
PMCID: PMC1262128

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implications of epidermal growth factor (EGF) induced egf receptor aggregation.PMID 1420877Read ↗

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.Semantic proximity Read ↗

Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.Semantic proximity Read ↗

An integrated mechanistic and data-driven computational model predicts cell responses to high- and low-affinity EGFR ligandsSemantic proximity Read ↗

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?Semantic proximity Read ↗

The single transmembrane domains of ErbB receptors self-associate in cell membranes.Semantic proximity Read ↗

Functional Effects of Glycosylation at Asn-579 of the Epidermal Growth Factor ReceptorSemantic proximity Read ↗

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling.Semantic proximity Read ↗

Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.Semantic proximity Read ↗

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.Semantic proximity Read ↗

EGFR forms ligand-independent oligomers that are distinct from the active state.Semantic proximity Read ↗

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer.Semantic proximity Read ↗

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.