Article
Implications of epidermal growth factor (EGF) induced egf receptor aggregation.
Biophysical journal - 1 Jul 1992
Wofsy C, Goldstein B, Lund K, Wiley H S
Abstract excerpt
To investigate the role of receptor aggregation in EGF binding, we construct a mathematical model describing receptor dimerization (and higher levels of aggregation) that permits an analysis of the influence of receptor aggregation on ligand binding. We answer two questions: (a) Can Scatchard plots of EGF binding data be analyzed productively in terms of two noninteracting receptor populations with different...
Topics
- Animals
- Binding Sites
- Biophysical Phenomena
- Biophysics
- Epidermal Growth Factor
- ErbB Receptors
- Kinetics
- L Cells
- Mice
- Models, Biological
- Mutation
- Protein Conformation