Increased expression and mutation of p53 in choroidal melanoma.

Abstract excerpt

Using CM-1 antibody directed against the human p53 protein, high levels of mutant p53 protein expression were found in 12 out of 18 malignant choroidal melanomas. In contrast, we failed to observe elevated p53 expression, indicating the absence of p53 mutation in seven choroidal naevi, a potentia...

Topics

• Animals
• Antibodies
• Base Sequence
• Blotting, Western
• Choroid Neoplasms
• Gene Expression
• Genes, p53
• Humans
• Melanoma
• Molecular Sequence Data
• Mutation
• Nevus
• Rabbits
• Tumor Suppressor Protein p53