Article
Whole body insulin sensitivity in Osborne-Mendel and S 5B/Pl rats eating a low- or high-fat diet.
The American journal of physiology - 1 Oct 1992
Buchanan T A, Fisler J S, Underberger S, Sipos G F, Bray G A
Abstract excerpt
To determine whether whole body insulin sensitivity differs between a rat strain that does not (S 5B/Pl) and a strain that does [Osborne-Mendel (OM)] become obese when eating a high-fat diet, we performed euglycemic clamp studies in animals from each strain during low- and high-fat feeding. Clamps were performed after 2 days ("initial clamp") and 9 days ("final clamp") on each diet. Plasma glucose and insulin...
Topics
- Analysis of Variance
- Animals
- Body Weight
- Dietary Fats
- Eating
- Female
- Genetic Predisposition to Disease
- Glucose Clamp Technique
- Insulin Resistance
- Obesity
- Rats