Article
Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity.
The Journal of clinical endocrinology and metabolism - 1 Nov 2015
Chen D L, Liess C, Poljak A, Xu A, Zhang J, Thoma C, Trenell M, Milner B, Jenkins A B, Chisholm D J, Samocha-Bonet D, Greenfield J R
Abstract excerpt
CONTEXT: Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive. OBJECTIVE: We examined phenotypic and metabolic factors associated with insulin sensitivity in both muscle and liver in obese individuals. DESIGN AND PARTICIPANTS: Sixty-four nondiabetic obese adults (29 males) underwent hyperinsulinemic (15 and 80 mU/m(2) · min)-euglycemic clamps with deuterated glucose. Top...
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