Article
Mutational activation of RAS and GSP oncogenes in differentiated thyroid cancer and their biological implications.
World journal of surgery - 1 Jan 2000
Goretzki P E, Lyons J, Stacy-Phipps S, Rosenau W, Demeure M, Clark O H, McCormick F, Röher H D, Bourne H R
Abstract excerpt
Activating mutations of ras-genes (Kirsten-ras, Harvey-ras, N-ras) and genes encoding for the alpha subunit of G-proteins (Gs, Gi2, Gi3, Go, Gz) were assessed in 32 differentiated thyroid cancer (DTC) tissues from German (n = 22) and American (n = 10) patients. Gs-protein (GSP) and/or ras mutatio...
Topics
- Base Sequence
- GTP-Binding Proteins
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Thyroid Neoplasms
- Tumor Cells, Cultured