Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations.

doi:10.1097/00007691-199206000-00002

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Article

Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations.

Therapeutic drug monitoring - 1 Jun 1992

Sohn D R, Kusaka M, Shin S G, Jang I J, Chiba K, Ishizaki T

Abstract excerpt

We examined the utility of the postdose 3-h plasma metabolic ratio (MR) as a phenotyping method for assessing genetically determined debrisoquine-type oxidation polymorphism after an oral dose of 100 mg of metoprolol tartrate administered to 402 unrelated, healthy, and native East Asian (218 Kore...

Topics

Adolescent
Adult
Asian People
Chromatography, High Pressure Liquid
Debrisoquin
Female
Humans
Japan
Korea
Male
Metoprolol
Middle Aged
Oxidation-Reduction
Phenotype

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