Article
Evidence for the polymorphic oxidation of debrisoquine in the Thai population.
British journal of clinical pharmacology - 1 Feb 1990
Wanwimolruk S, Patamasucon P, Lee E J
Abstract excerpt
Debrisoquine polymorphism has been studied extensively in Caucasian populations. The prevalence of the poor metaboliser phenotype is 3-10% in European and American Caucasian populations but appears to be very low in Asian populations. This study was carried out to determine the metabolic oxidation status in 173 Thai subjects. Phenotyping was performed using the metabolic ratio (MR) calculated as the 0-8 h urinary...
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