Metoprolol alpha-hydroxylation capacity in 96 Chinese Han volunteers.

Article

Metoprolol alpha-hydroxylation capacity in 96 Chinese Han volunteers.

Zhongguo yao li xue bao = Acta pharmacologica Sinica - 1 Jul 1995

Tu Z G, Zhao L L

Abstract excerpt

AIM: To study the ability of oxidizing metoprolol (Met) to form alpha-hydroxymetoprolol (HM) in Chinese in vivo and in vitro. METHODS: An ion-pair reverse phase high performance liquid chromatography was used. RESULTS: In vivo study, the 8-h urinary recoveries of Met and HM after po Met tartrate...

Topics

Asian People
China
Female
Humans
Hydroxylation
Male
Metabolic Clearance Rate
Metoprolol
Microsomes, Liver
Phenotype
Polymorphism, Genetic

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