Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (+/-)-metoprolol.

doi:10.1007/BF00315352

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Article

Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (+/-)-metoprolol.

European journal of clinical pharmacology - 1 Jan 1993

Leemann T D, Devi K P, Dayer P

Abstract excerpt

The influence of phenotype (debrisoquine type of oxidation polymorphism) and quinidine on (+/-)-metoprolol distribution parameters was investigated in 7 young male volunteers (4 extensive and 3 poor metabolisers). (+/-)-Metoprolol tartrate 20 mg was administered as a 20 min infusion i) alone, ii)...

Topics

Adult
Blood Proteins
Debrisoquin
Drug Interactions
Humans
Male
Metoprolol
Phenotype
Polymorphism, Genetic
Protein Binding
Quinidine

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